human leukocyte antigen-g expression on dendritic cells induced by transforming growth factor-β1 and cd4+ t cells proliferation
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abstract
background: during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. dc are antigen-presenting cells that have an important role in tolerance and autoimmunity. the transforming growth factor-beta1 (tgf-β1) cytokine has a regulatory role on the immune and non-immune cells. the aim of this study is to evaluate the effect of tgf-β1 on the induction of human leukocyte antigen-g (hla-g) expression on the dc which is derived from monocyte. methods: in this study, we evaluated the effect of tgf-β1 in induction hla-g expression on the monocyte-derived dc by flowcytometry and then cd4+ t cell proliferative responses in the presence of dc-treated tgf-β1 was studied. results: the results of this study showed that dc bearing hla-g down-regulated activation of cd4+ t cells and production of il-6 and il-17 in comparison with control (p<0.05). conclusion: it is concluded that tgf-β1 has an important regulatory role in cd4+ t cell proliferation by increasing hla-g on dc and these cells can probably prevent unexpected immune responses in vivo.
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Journal title:
iranian biomedical journalجلد ۱۵، شماره ۱، صفحات ۱-۵
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